Some 300 miles south of Chicago (some 4½ hours without stopping, though trust me, you won't want to miss out on at least some of these nearly three dozen cool places to catch along the way), the "gateway to the American West" is one of the biggest (pop. 302,000) and most prominent cities on Route 66. Its downtown is dominated by the iconic Gateway Arch, rising 630 feet above the Mississippi River, and visitors can ride to the top for panoramic views. Other fantastic options include cruises along the Mississipi, exploring the rich blues heritage as well as more than three dozen museums and historical sites; and enjoying some of the Midwest's best barbecue.
Read more in my post Route 66 at 100: 5 Key Destinations on the USA´s Iconic, Historica "Mother Road."
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